منابع مشابه
Watching a DNA polymerase in action
DNA polymerase (pol) β is a model eukaryotic DNA polymerase due to its small size, stability in structural studies, and significant biological role during DNA repair. Previous studies had determined that pol β binds to single-nucleotide gapped DNA in an open conformation. Upon binding an incoming nucleoside triphosphate and 2 metal ions, pol β undergoes a conformational change to form a pre-cat...
متن کاملWatching the DNA Repair Ensemble Dance
Repair of damaged DNA is a dynamic process that requires careful orchestration of a multitude of enzymes, adaptor proteins, and chromatin constituents. In this issue of Cell, Lisby et al. (2004) provide a visual glimpse into how the diverse signaling and repair machines are organized in space and time around the deadliest genetic lesions--the DNA double-strand breaks.
متن کاملWatching DNA repair in real time.
I n 1949, Albert Kelner described a miraculous recovery of cells damaged by UV radiation when cells were exposed to soft sunlight (1). It was found later that an enzyme photolyase (PL) is involved in photoreactivation (2). With a paper in PNAS by Dongping Zhong, Aziz Sancar, and their colleagues (3) describing the real-time progression of the photoreactivation repair reaction observed by femtos...
متن کاملMolecular electronics: DNA charges ahead.
Some sequences of DNA conduct charge better than others. Replacing adenine with an analogue allows more sequences to transport charge effectively.
متن کاملCharge transfer in DNA*
In the past few decades, charge transfer in DNA has attracted considerable attention from researchers in a wide variety of fields ranging from bioscience and physical chemistry to nanotechnology. Charge transfer in DNA has been investigated using various techniques. Among them, time-resolved spectroscopic methods have provided information on chargetransfer dynamics in DNA, an important basis fo...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.335.6066.265-b